APT IMAGING OF HEPATOCELLULAR CARCINOMA SIGNALS AN EFFECTIVE THERAPEUTIC RESPONSE IN ADVANCE OF TUMOR SHRINKAGE

Aim: The aim of this study was to assess the utility of weighted amide proton transfer (APTw) MRI in three different rodent models of hepatocellular carcinoma (HCC).Methods: APTw MRI was evaluated in models of diethylnitrosamine (DEN) induced HCC, N1S1 syngeneic orthotopic xenograft and human Feature HepG2 ectopic xenograft.Results: All models of H